Home TGF-beta/Smad -Stem Cells & Wnt TGF-beta/Smad TGFβRII Inhibitors

TGFβRII Inhibitors

  • ALK1
  • ALK2
  • ALK3
  • ALK4
  • TGFβRI/ALK5
  • ALK6
  • TGFβRII
  • TGF-β
N° Cat. Nom du produit Information Sélectif / Pan IC50 / Ki
S2704 LY2109761 LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2. Pan TβRII, Ki: 300 nM
S2805 LY364947 LY364947 is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, shows 7-fold selectivity over TGFβR-II. Pan TGFβRII, IC50: 0.4 μM