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APC inhibiteurs (APC Inhibitors)

Anaphase-Promoting Complex (APC) which is also called cyclosome, a highly conserved protein, plays a key role in both cell cycle and Ubq degradation pathway. The APC can results in degradation of specific proteins which are involved in cell cycle by tagging those proteins during the transition from metaphase to anaphase. When spindle checkpoint is silenced, APC can easily bind to Cdc20 after phosphorylated by M-Cdks. Then APC targets cyclin A and cyclin B for degradation.

Autre Cell Cycle Inhibiteurs

CDK ROCK Wee1 Aurora Kinase Chk PLK MPS1 Rho Myc DYRK
N° Cat. Nom du produit Information Citations dutilisation du produit Validations de produits
S2225 TAME Le Tosyl-L-Arginine Methyl Ester (TAME) est un inhibiteur de l'APC.
Dev Cell, 2023, 58(3):192-210.e11
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
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S9605 Apcin Apcin (inhibiteur de l'APC) est un inhibiteur de l'activité E3 Ligase du complexe/cyclosome promoteur de l'anaphase (APC/C) mitotique qui se lie à Cdc20 et inhibe de manière compétitive l'ubiquitination des substrats contenant une D-box.
Nature, 2025, 647(8091):952-961
Theranostics, 2025, 15(8):3439-3461
Cell Mol Biol Lett, 2025, 30(1):29