pour la recherche uniquement

Navitoclax (ABT-263) Bcl-2 inhibiteur

Name: Navitoclax (ABT-263)
Brand: Selleck Chemicals
SKU: S1001
Rating: 5 (399 reviews)

Réf. CatalogueS1001

Puissant inhibiteur de Bcl-xL, Bcl-2 et Bcl-w avec des K_i de ", "0,5 nM, ", "1 nM et ", "1 nM dans les essais sans cellules, Navitoclax (ABT-263) se lie plus faiblement à Mcl-1 et A1. Phase 2.

Navitoclax (ABT-263) Bcl-2 inhibiteur Chemical Structure

Structure chimique

Poids moléculaire: 974.61

Aller à

Contrôle Qualité

Lot : Pureté : 99.86%

99.86

Produits souvent utilisés avec Navitoclax (ABT-263)

A-1331852

It and A-1331852 selectively induce apoptosis in senescent endothelial cells (ECs).

ABT-737

It and ABT-737 induce BAK/BAX-mediated platelet apoptosis by pharmacologically suppressing BCL-XL.

MG132

This compound and MG132 plus GX15-070 partially restore the protein expression of Bcl-2-associated athanogene domain 3 (Bag3) and the deubiquitinase Usp9X in LN229 glioblastoma cells.

Y-27632 Dihydrochloride

It and Y-27632 2HCl synergistically enhance mitochondrial priming and provide a potential therapeutic strategy for scleroderma fibroblast apoptosis.

Cibles apparentées	Caspase PD-1/PD-L1 Ferroptosis p53 Apoptosis related Synthetic Lethality STAT TNF-alpha Ras KRas
Autre Bcl-2 Inhibiteurs	S63845 Obatoclax Mesylate (GX15-070) A-1210477 TW-37 A-1155463 Dihydrochloride AZD5991 UMI-77 (R)-(-)-Gossypol (AT-101) acetic acid A-1155463 Sabutoclax

Culture cellulaire, traitement et concentration de travail

Lignées cellulaires	Type dessai	Temps dincubation	Description de lactivité	PMID
FL5.12	Cytotoxicity assay	24 h	EC50 = 0.0042 μM	18841882
FL5.12	Cytotoxicity assay	24 h	EC50 = 0.0059 μM	18841882
RS4:11	Apoptosis assay	6 h	EC50 = 0.014 μM	24881567
FDC-P1	BCL-2 inhibition assay	24 h	IC50 = 0.015 μM	24881567
NCI-H1963	Cytotoxicity assay	4 days	IC50 = 0.0266 μM	23448298
NCI-H187	Cytotoxicity assay	4 days	IC50 = 0.0384 μM	23448298
NCI-H1417	Cytotoxicity assay	4 days	IC50 = 0.0542 μM	23448298
FDC-P1	BCL-xL inhibition assay	24 h	IC50 = 0.06 μM	24881567
NCI-H146	Cytotoxicity assay	48 h	EC50 = 0.0867 μM	18841882
RS4:11	Antiproliferative activity assay		EC50 = 0.112 μM	28926247
MOLT4	Antiproliferative activity assay		EC50 = 0.303 μM	28926247
EoL-1-cell	Growth Inhibition Assay		IC50=0.00669 μM	SANGER
MV-4-11	Growth Inhibition Assay		IC50=0.01586 μM	SANGER
NKM-1	Growth Inhibition Assay		IC50=0.01699 μM	SANGER
ML-2	Growth Inhibition Assay		IC50=0.01983 μM	SANGER
BV-173	Growth Inhibition Assay		IC50=0.02314 μM	SANGER
RS4-11	Growth Inhibition Assay		IC50=0.02587 μM	SANGER
HL-60	Growth Inhibition Assay		IC50=0.02908 μM	SANGER
KY821	Growth Inhibition Assay		IC50=0.02975 μM	SANGER
ECC10	Growth Inhibition Assay		IC50=0.03792 μM	SANGER
NCI-H720	Growth Inhibition Assay		IC50=0.04011 μM	SANGER
QIMR-WIL	Growth Inhibition Assay		IC50=0.04287 μM	SANGER
KG-1	Growth Inhibition Assay		IC50=0.04486 μM	SANGER
TGW	Growth Inhibition Assay		IC50=0.04633 μM	SANGER
ATN-1	Growth Inhibition Assay		IC50=0.04733 μM	SANGER
RH-18	Growth Inhibition Assay		IC50=0.06048 μM	SANGER
EW-18	Growth Inhibition Assay		IC50=0.06841 μM	SANGER
NB17	Growth Inhibition Assay		IC50=0.07124 μM	SANGER
SK-NEP-1	Growth Inhibition Assay		IC50=0.07213 μM	SANGER
P12-ICHIKAWA	Growth Inhibition Assay		IC50=0.07778 μM	SANGER
KARPAS-45	Growth Inhibition Assay		IC50=0.07815 μM	SANGER
EW-3	Growth Inhibition Assay		IC50=0.08053 μM	SANGER
NB13	Growth Inhibition Assay		IC50=0.08203 μM	SANGER
NCI-H209	Growth Inhibition Assay		IC50=0.08704 μM	SANGER
NCI-H1092	Growth Inhibition Assay		IC50=0.10275 μM	SANGER
NH-12	Growth Inhibition Assay		IC50=0.10744 μM	SANGER
697	Growth Inhibition Assay		IC50=0.10839 μM	SANGER
KE-37	Growth Inhibition Assay		IC50=0.1137 μM	SANGER
MOLT-4	Growth Inhibition Assay		IC50=0.15169 μM	SANGER
CHP-134	Growth Inhibition Assay		IC50=0.16306 μM	SANGER
D-283MED	Growth Inhibition Assay		IC50=0.17686 μM	SANGER
LU-135	Growth Inhibition Assay		IC50=0.18552 μM	SANGER
LU-134-A	Growth Inhibition Assay		IC50=0.18671 μM	SANGER
EM-2	Growth Inhibition Assay		IC50=0.19918 μM	SANGER
LU-139	Growth Inhibition Assay		IC50=0.20498 μM	SANGER
ALL-PO	Growth Inhibition Assay		IC50=0.21988 μM	SANGER
NB12	Growth Inhibition Assay		IC50=0.23115 μM	SANGER
KP-N-YN	Growth Inhibition Assay		IC50=0.23573 μM	SANGER
BEN	Growth Inhibition Assay		IC50=0.23968 μM	SANGER
HCC1569	Growth Inhibition Assay		IC50=0.25106 μM	SANGER
HuO9	Growth Inhibition Assay		IC50=0.26715 μM	SANGER
WM-115	Growth Inhibition Assay		IC50=0.27738 μM	SANGER
CCRF-CEM	Growth Inhibition Assay		IC50=0.33529 μM	SANGER
IST-SL1	Growth Inhibition Assay		IC50=0.35343 μM	SANGER
BE-13	Growth Inhibition Assay		IC50=0.36459 μM	SANGER
COR-L88	Growth Inhibition Assay		IC50=0.3654 μM	SANGER
DOHH-2	Growth Inhibition Assay		IC50=0.41023 μM	SANGER
A704	Growth Inhibition Assay		IC50=0.4267 μM	SANGER
KNS-81-FD	Growth Inhibition Assay		IC50=0.44017 μM	SANGER
RPMI-8226	Growth Inhibition Assay		IC50=0.45652 μM	SANGER
TGBC24TKB	Growth Inhibition Assay		IC50=0.45778 μM	SANGER
NCI-H1304	Growth Inhibition Assay		IC50=0.46157 μM	SANGER
MOLT-13	Growth Inhibition Assay		IC50=0.46613 μM	SANGER
EW-22	Growth Inhibition Assay		IC50=0.46671 μM	SANGER
MS-1	Growth Inhibition Assay		IC50=0.46933 μM	SANGER
RMG-I	Growth Inhibition Assay		IC50=0.49464 μM	SANGER
NTERA-S-cl-D1	Growth Inhibition Assay		IC50=0.50019 μM	SANGER
NCI-H1048	Growth Inhibition Assay		IC50=0.50953 μM	SANGER
SW1417	Growth Inhibition Assay		IC50=0.55438 μM	SANGER
DB	Growth Inhibition Assay		IC50=0.5708 μM	SANGER
MEG-01	Growth Inhibition Assay		IC50=0.5832 μM	SANGER
EW-13	Growth Inhibition Assay		IC50=0.58341 μM	SANGER
LAMA-84	Growth Inhibition Assay		IC50=0.59207 μM	SANGER
J-RT3-T3-5	Growth Inhibition Assay		IC50=0.60808 μM	SANGER
MOLT-16	Growth Inhibition Assay		IC50=0.65264 μM	SANGER
DU-4475	Growth Inhibition Assay		IC50=0.65427 μM	SANGER
HAL-01	Growth Inhibition Assay		IC50=0.72549 μM	SANGER
RD	Growth Inhibition Assay		IC50=0.75899 μM	SANGER
OAW-28	Growth Inhibition Assay		IC50=0.7837 μM	SANGER
HCC38	Growth Inhibition Assay		IC50=0.8019 μM	SANGER
NMC-G1	Growth Inhibition Assay		IC50=0.81121 μM	SANGER
EW-16	Growth Inhibition Assay		IC50=0.81328 μM	SANGER
DU-145	Growth Inhibition Assay		IC50=0.89923 μM	SANGER
HPAF-II	Growth Inhibition Assay		IC50=0.92628 μM	SANGER
A427	Growth Inhibition Assay		IC50=0.93022 μM	SANGER
PA-1	Growth Inhibition Assay		IC50=0.95642 μM	SANGER
OAW-42	Growth Inhibition Assay		IC50=0.96146 μM	SANGER
L-428	Growth Inhibition Assay		IC50=1.0125 μM	SANGER
COLO-824	Growth Inhibition Assay		IC50=1.01708 μM	SANGER
P30-OHK	Growth Inhibition Assay		IC50=1.04688 μM	SANGER
NCI-H2170	Growth Inhibition Assay		IC50=1.0623 μM	SANGER
HCC2998	Growth Inhibition Assay		IC50=1.07135 μM	SANGER
NB14	Growth Inhibition Assay		IC50=1.13748 μM	SANGER
TGBC1TKB	Growth Inhibition Assay		IC50=1.14152 μM	SANGER
KP-N-YS	Growth Inhibition Assay		IC50=1.16236 μM	SANGER
CAL-120	Growth Inhibition Assay		IC50=1.16429 μM	SANGER
SBC-1	Growth Inhibition Assay		IC50=1.19053 μM	SANGER
C32	Growth Inhibition Assay		IC50=1.19088 μM	SANGER
HCC2157	Growth Inhibition Assay		IC50=1.19494 μM	SANGER
COLO-792	Growth Inhibition Assay		IC50=1.20071 μM	SANGER
ES7	Growth Inhibition Assay		IC50=1.27951 μM	SANGER
HEL	Growth Inhibition Assay		IC50=1.31029 μM	SANGER
ES4	Growth Inhibition Assay		IC50=1.34998 μM	SANGER
NCI-SNU-1	Growth Inhibition Assay		IC50=1.36555 μM	SANGER
MDA-MB-415	Growth Inhibition Assay		IC50=1.3885 μM	SANGER
NCI-H2342	Growth Inhibition Assay		IC50=1.40269 μM	SANGER
NB69	Growth Inhibition Assay		IC50=1.46271 μM	SANGER
D-247MG	Growth Inhibition Assay		IC50=1.51122 μM	SANGER
SCC-4	Growth Inhibition Assay		IC50=1.59887 μM	SANGER
HuH-7	Growth Inhibition Assay		IC50=1.67293 μM	SANGER
A388	Growth Inhibition Assay		IC50=1.68724 μM	SANGER
Calu-3	Growth Inhibition Assay		IC50=1.70697 μM	SANGER
NCI-H1648	Growth Inhibition Assay		IC50=1.71418 μM	SANGER
NCI-H2052	Growth Inhibition Assay		IC50=1.72201 μM	SANGER
Ramos-2G6-4C10	Growth Inhibition Assay		IC50=1.73656 μM	SANGER
DEL	Growth Inhibition Assay		IC50=1.74692 μM	SANGER
SNU-423	Growth Inhibition Assay		IC50=1.78157 μM	SANGER
COR-L23	Growth Inhibition Assay		IC50=1.79874 μM	SANGER
OMC-1	Growth Inhibition Assay		IC50=1.86016 μM	SANGER
EW-11	Growth Inhibition Assay		IC50=1.95657 μM	SANGER
HSC-3	Growth Inhibition Assay		IC50=1.96365 μM	SANGER
MLMA	Growth Inhibition Assay		IC50=1.96677 μM	SANGER
RCM-1	Growth Inhibition Assay		IC50=2.00399 μM	SANGER
MFE-280	Growth Inhibition Assay		IC50=2.02848 μM	SANGER
ES8	Growth Inhibition Assay		IC50=2.25471 μM	SANGER
TE-11	Growth Inhibition Assay		IC50=2.29473 μM	SANGER
HuO-3N1	Growth Inhibition Assay		IC50=2.4878 μM	SANGER
MHH-NB-11	Growth Inhibition Assay		IC50=2.51158 μM	SANGER
TGBC11TKB	Growth Inhibition Assay		IC50=2.57681 μM	SANGER
HOP-92	Growth Inhibition Assay		IC50=2.58743 μM	SANGER
IGR-1	Growth Inhibition Assay		IC50=2.62035 μM	SANGER
GOTO	Growth Inhibition Assay		IC50=2.65377 μM	SANGER
NCI-H1650	Growth Inhibition Assay		IC50=2.72215 μM	SANGER
NCI-H1581	Growth Inhibition Assay		IC50=2.79681 μM	SANGER
NCI-H2405	Growth Inhibition Assay		IC50=2.82782 μM	SANGER
U-118-MG	Growth Inhibition Assay		IC50=2.96491 μM	SANGER
DoTc2-4510	Growth Inhibition Assay		IC50=3.01417 μM	SANGER
NCI-H596	Growth Inhibition Assay		IC50=3.04997 μM	SANGER
MPP-89	Growth Inhibition Assay		IC50=3.05666 μM	SANGER
GCIY	Growth Inhibition Assay		IC50=3.20491 μM	SANGER
SW626	Growth Inhibition Assay		IC50=3.24543 μM	SANGER
OCI-AML2	Growth Inhibition Assay		IC50=3.31272 μM	SANGER
NBsusSR	Growth Inhibition Assay		IC50=3.34938 μM	SANGER
AN3-CA	Growth Inhibition Assay		IC50=3.44238 μM	SANGER
EFM-19	Growth Inhibition Assay		IC50=3.48339 μM	SANGER
RVH-421	Growth Inhibition Assay		IC50=3.56877 μM	SANGER
5637	Growth Inhibition Assay		IC50=3.61103 μM	SANGER
PANC-08-13	Growth Inhibition Assay		IC50=3.63472 μM	SANGER
H9	Growth Inhibition Assay		IC50=3.67144 μM	SANGER
KARPAS-299	Growth Inhibition Assay		IC50=3.67361 μM	SANGER
TE-5	Growth Inhibition Assay		IC50=3.70709 μM	SANGER
NOS-1	Growth Inhibition Assay		IC50=3.79834 μM	SANGER
HH	Growth Inhibition Assay		IC50=3.83868 μM	SANGER
769-P	Growth Inhibition Assay		IC50=3.8951 μM	SANGER
CHP-212	Growth Inhibition Assay		IC50=3.92549 μM	SANGER
NCI-H82	Growth Inhibition Assay		IC50=3.95936 μM	SANGER
Mo-T	Growth Inhibition Assay		IC50=4.04312 μM	SANGER
BB65-RCC	Growth Inhibition Assay		IC50=4.04399 μM	SANGER
SW1990	Growth Inhibition Assay		IC50=4.05908 μM	SANGER
LK-2	Growth Inhibition Assay		IC50=4.11293 μM	SANGER
ES5	Growth Inhibition Assay		IC50=4.13985 μM	SANGER
JVM-3	Growth Inhibition Assay		IC50=4.18222 μM	SANGER
RPMI-7951	Growth Inhibition Assay		IC50=4.22413 μM	SANGER
Calu-6	Growth Inhibition Assay		IC50=4.27881 μM	SANGER
LC-2-ad	Growth Inhibition Assay		IC50=4.29568 μM	SANGER
SW954	Growth Inhibition Assay		IC50=4.2966 μM	SANGER
H-EMC-SS	Growth Inhibition Assay		IC50=4.31831 μM	SANGER
ES3	Growth Inhibition Assay		IC50=4.35441 μM	SANGER
no-11	Growth Inhibition Assay		IC50=4.35554 μM	SANGER
LAN-6	Growth Inhibition Assay		IC50=4.45189 μM	SANGER
FTC-133	Growth Inhibition Assay		IC50=4.5395 μM	SANGER
8505C	Growth Inhibition Assay		IC50=4.5423 μM	SANGER
SW620	Growth Inhibition Assay		IC50=4.57057 μM	SANGER
BCPAP	Growth Inhibition Assay		IC50=4.63481 μM	SANGER
SK-LU-1	Growth Inhibition Assay		IC50=4.66089 μM	SANGER
NCI-H1623	Growth Inhibition Assay		IC50=4.70228 μM	SANGER
C2BBe1	Growth Inhibition Assay		IC50=4.74008 μM	SANGER
GP5d	Growth Inhibition Assay		IC50=4.78388 μM	SANGER
NB6	Growth Inhibition Assay		IC50=4.86204 μM	SANGER
MDA-MB-157	Growth Inhibition Assay		IC50=4.8876 μM	SANGER
UMC-11	Growth Inhibition Assay		IC50=4.88964 μM	SANGER
HCC1419	Growth Inhibition Assay		IC50=4.90063 μM	SANGER
NCI-H2029	Growth Inhibition Assay		IC50=4.94185 μM	SANGER
LXF-289	Growth Inhibition Assay		IC50=5.03719 μM	SANGER
KINGS-1	Growth Inhibition Assay		IC50=5.07744 μM	SANGER
HD-MY-Z	Growth Inhibition Assay		IC50=5.23969 μM	SANGER
ESS-1	Growth Inhibition Assay		IC50=5.25597 μM	SANGER
GI-1	Growth Inhibition Assay		IC50=5.27926 μM	SANGER
RPMI-2650	Growth Inhibition Assay		IC50=5.3616 μM	SANGER
IA-LM	Growth Inhibition Assay		IC50=5.39871 μM	SANGER
KP-4	Growth Inhibition Assay		IC50=5.46334 μM	SANGER
G-402	Growth Inhibition Assay		IC50=5.51865 μM	SANGER
OS-RC-2	Growth Inhibition Assay		IC50=5.52604 μM	SANGER
NCI-H1155	Growth Inhibition Assay		IC50=5.54955 μM	SANGER
OE19	Growth Inhibition Assay		IC50=5.68624 μM	SANGER
U-2-OS	Growth Inhibition Assay		IC50=5.89013 μM	SANGER
SCC-15	Growth Inhibition Assay		IC50=5.93662 μM	SANGER
NCI-H630	Growth Inhibition Assay		IC50=5.99404 μM	SANGER
PFSK-1	Growth Inhibition Assay		IC50=6.05259 μM	SANGER
NCI-H1770	Growth Inhibition Assay		IC50=6.20874 μM	SANGER
SK-MEL-3	Growth Inhibition Assay		IC50=6.42915 μM	SANGER
LB1047-RCC	Growth Inhibition Assay		IC50=6.47625 μM	SANGER
NCI-H446	Growth Inhibition Assay		IC50=6.62925 μM	SANGER
SW780	Growth Inhibition Assay		IC50=6.70185 μM	SANGER
NEC8	Growth Inhibition Assay		IC50=6.7663 μM	SANGER
NOMO-1	Growth Inhibition Assay		IC50=6.78111 μM	SANGER
COLO-668	Growth Inhibition Assay		IC50=6.84387 μM	SANGER
MC116	Growth Inhibition Assay		IC50=6.93897 μM	SANGER
HCC1937	Growth Inhibition Assay		IC50=6.99251 μM	SANGER
NCI-N87	Growth Inhibition Assay		IC50=7.19293 μM	SANGER
COLO-320-HSR	Growth Inhibition Assay		IC50=7.22738 μM	SANGER
HCC1806	Growth Inhibition Assay		IC50=7.26044 μM	SANGER
OVCAR-3	Growth Inhibition Assay		IC50=7.33038 μM	SANGER
NUGC-3	Growth Inhibition Assay		IC50=7.39694 μM	SANGER
SW1783	Growth Inhibition Assay		IC50=7.43175 μM	SANGER
GCT	Growth Inhibition Assay		IC50=7.56906 μM	SANGER
NCI-H2126	Growth Inhibition Assay		IC50=7.73625 μM	SANGER
MEL-HO	Growth Inhibition Assay		IC50=7.77054 μM	SANGER
CAPAN-1	Growth Inhibition Assay		IC50=7.77357 μM	SANGER
SW756	Growth Inhibition Assay		IC50=7.78333 μM	SANGER
SKG-IIIa	Growth Inhibition Assay		IC50=7.81892 μM	SANGER
HCE-T	Growth Inhibition Assay		IC50=7.87783 μM	SANGER
Ca-Ski	Growth Inhibition Assay		IC50=7.99383 μM	SANGER
COLO-684	Growth Inhibition Assay		IC50=8.01818 μM	SANGER
KYSE-70	Growth Inhibition Assay		IC50=8.07729 μM	SANGER
TI-73	Growth Inhibition Assay		IC50=8.25851 μM	SANGER
BT-20	Growth Inhibition Assay		IC50=8.26052 μM	SANGER
MHH-ES-1	Growth Inhibition Assay		IC50=8.51834 μM	SANGER
TE-12	Growth Inhibition Assay		IC50=8.59931 μM	SANGER
YH-13	Growth Inhibition Assay		IC50=8.61008 μM	SANGER
SF126	Growth Inhibition Assay		IC50=8.83865 μM	SANGER
J82	Growth Inhibition Assay		IC50=8.90038 μM	SANGER
RCC10RGB	Growth Inhibition Assay		IC50=8.99561 μM	SANGER
SK-UT-1	Growth Inhibition Assay		IC50=9.04945 μM	SANGER
LB2241-RCC	Growth Inhibition Assay		IC50=9.19137 μM	SANGER
LB996-RCC	Growth Inhibition Assay		IC50=9.1989 μM	SANGER
EPLC-272H	Growth Inhibition Assay		IC50=9.37657 μM	SANGER
CTV-1	Growth Inhibition Assay		IC50=9.56532 μM	SANGER
HSC-2	Growth Inhibition Assay		IC50=9.5755 μM	SANGER
SK-MEL-28	Growth Inhibition Assay		IC50=9.61893 μM	SANGER
MMAC-SF	Growth Inhibition Assay		IC50=9.6875 μM	SANGER
CP50-MEL-B	Growth Inhibition Assay		IC50=9.75782 μM	SANGER
HT-1080	Growth Inhibition Assay		IC50=9.77739 μM	SANGER
HEC-1	Growth Inhibition Assay		IC50=10.3352 μM	SANGER
AGS	Growth Inhibition Assay		IC50=10.374 μM	SANGER
GAMG	Growth Inhibition Assay		IC50=10.5162 μM	SANGER
SW48	Growth Inhibition Assay		IC50=10.5189 μM	SANGER
U031	Growth Inhibition Assay		IC50=10.5908 μM	SANGER
OVCAR-5	Growth Inhibition Assay		IC50=10.6429 μM	SANGER
SF295	Growth Inhibition Assay		IC50=10.6704 μM	SANGER
BHT-101	Growth Inhibition Assay		IC50=10.7177 μM	SANGER
VMRC-RCZ	Growth Inhibition Assay		IC50=11.3201 μM	SANGER
ACHN	Growth Inhibition Assay		IC50=11.4211 μM	SANGER
NCI-H526	Growth Inhibition Assay		IC50=11.5043 μM	SANGER
MN-60	Growth Inhibition Assay		IC50=11.539 μM	SANGER
NCI-H2291	Growth Inhibition Assay		IC50=11.5466 μM	SANGER
SCC-25	Growth Inhibition Assay		IC50=11.7556 μM	SANGER
SK-MEL-2	Growth Inhibition Assay		IC50=11.7637 μM	SANGER
SN12C	Growth Inhibition Assay		IC50=11.9355 μM	SANGER
NCI-H69	Growth Inhibition Assay		IC50=12.4234 μM	SANGER
ME-180	Growth Inhibition Assay		IC50=12.7054 μM	SANGER
MC-IXC	Growth Inhibition Assay		IC50=12.7518 μM	SANGER
NCI-H2347	Growth Inhibition Assay		IC50=12.7614 μM	SANGER
M059J	Growth Inhibition Assay		IC50=12.7727 μM	SANGER
A2058	Growth Inhibition Assay		IC50=12.8681 μM	SANGER
VA-ES-BJ	Growth Inhibition Assay		IC50=12.8785 μM	SANGER
Ca9-22	Growth Inhibition Assay		IC50=12.9451 μM	SANGER
KNS-42	Growth Inhibition Assay		IC50=12.9984 μM	SANGER
LoVo	Growth Inhibition Assay		IC50=13.2313 μM	SANGER
AM-38	Growth Inhibition Assay		IC50=13.2566 μM	SANGER
NB5	Growth Inhibition Assay		IC50=13.3752 μM	SANGER
L-363	Growth Inhibition Assay		IC50=13.4033 μM	SANGER
SK-MEL-30	Growth Inhibition Assay		IC50=14.0645 μM	SANGER
NCI-H1563	Growth Inhibition Assay		IC50=14.6039 μM	SANGER
NCI-H2228	Growth Inhibition Assay		IC50=14.6077 μM	SANGER
MFM-223	Growth Inhibition Assay		IC50=15.1813 μM	SANGER
LB831-BLC	Growth Inhibition Assay		IC50=15.2767 μM	SANGER
SW872	Growth Inhibition Assay		IC50=15.3086 μM	SANGER
NCI-H522	Growth Inhibition Assay		IC50=15.3306 μM	SANGER
EW-1	Growth Inhibition Assay		IC50=15.5462 μM	SANGER
HN	Growth Inhibition Assay		IC50=15.5942 μM	SANGER
SW837	Growth Inhibition Assay		IC50=15.7847 μM	SANGER
SCC-9	Growth Inhibition Assay		IC50=15.8114 μM	SANGER
MKN7	Growth Inhibition Assay		IC50=15.9732 μM	SANGER
KYSE-410	Growth Inhibition Assay		IC50=16.591 μM	SANGER
SK-N-DZ	Growth Inhibition Assay		IC50=16.6116 μM	SANGER
COR-L105	Growth Inhibition Assay		IC50=16.6528 μM	SANGER
LB2518-MEL	Growth Inhibition Assay		IC50=16.8389 μM	SANGER
OVCAR-4	Growth Inhibition Assay		IC50=16.8862 μM	SANGER
TK10	Growth Inhibition Assay		IC50=16.9473 μM	SANGER
KNS-62	Growth Inhibition Assay		IC50=16.9777 μM	SANGER
RPMI-8866	Growth Inhibition Assay		IC50=17.1732 μM	SANGER
HuP-T4	Growth Inhibition Assay		IC50=17.2495 μM	SANGER
CGTH-W-1	Growth Inhibition Assay		IC50=17.5219 μM	SANGER
T-24	Growth Inhibition Assay		IC50=17.5347 μM	SANGER
HT-3	Growth Inhibition Assay		IC50=17.5914 μM	SANGER
KS-1	Growth Inhibition Assay		IC50=17.673 μM	SANGER
NCI-H1792	Growth Inhibition Assay		IC50=17.798 μM	SANGER
ABC-1	Growth Inhibition Assay		IC50=17.8141 μM	SANGER
BPH-1	Growth Inhibition Assay		IC50=18.1685 μM	SANGER
A431	Growth Inhibition Assay		IC50=18.4127 μM	SANGER
T98G	Growth Inhibition Assay		IC50=18.5157 μM	SANGER
BHY	Growth Inhibition Assay		IC50=18.869 μM	SANGER
Capan-2	Growth Inhibition Assay		IC50=18.9078 μM	SANGER
MDA-MB-175-VII	Growth Inhibition Assay		IC50=18.9209 μM	SANGER
CAL-27	Growth Inhibition Assay		IC50=19.0487 μM	SANGER
AsPC-1	Growth Inhibition Assay		IC50=19.8657 μM	SANGER
KU812	Growth Inhibition Assay		IC50=19.9573 μM	SANGER
NCI-H441	Growth Inhibition Assay		IC50=20.001 μM	SANGER
Mewo	Growth Inhibition Assay		IC50=20.1288 μM	SANGER
SK-MEL-24	Growth Inhibition Assay		IC50=20.1477 μM	SANGER
NCI-H727	Growth Inhibition Assay		IC50=20.2704 μM	SANGER
EKVX	Growth Inhibition Assay		IC50=20.606 μM	SANGER
RT-112	Growth Inhibition Assay		IC50=20.6122 μM	SANGER
CAMA-1	Growth Inhibition Assay		IC50=20.9803 μM	SANGER
SW900	Growth Inhibition Assay		IC50=21.0149 μM	SANGER
NCI-H23	Growth Inhibition Assay		IC50=21.1277 μM	SANGER
SK-PN-DW	Growth Inhibition Assay		IC50=21.1649 μM	SANGER
BB30-HNC	Growth Inhibition Assay		IC50=21.2745 μM	SANGER
VM-CUB-1	Growth Inhibition Assay		IC50=21.3536 μM	SANGER
IST-MEL1	Growth Inhibition Assay		IC50=21.3692 μM	SANGER
CTB-1	Growth Inhibition Assay		IC50=21.4755 μM	SANGER
LCLC-103H	Growth Inhibition Assay		IC50=22.1582 μM	SANGER
PANC-03-27	Growth Inhibition Assay		IC50=22.5169 μM	SANGER
HTC-C3	Growth Inhibition Assay		IC50=22.5555 μM	SANGER
TE-8	Growth Inhibition Assay		IC50=23.2565 μM	SANGER
NCI-H292	Growth Inhibition Assay		IC50=25.3536 μM	SANGER
COLO-680N	Growth Inhibition Assay		IC50=25.6329 μM	SANGER
KYSE-520	Growth Inhibition Assay		IC50=25.644 μM	SANGER
NB10	Growth Inhibition Assay		IC50=26.3117 μM	SANGER
NCI-H661	Growth Inhibition Assay		IC50=26.4713 μM	SANGER
GMS-10	Growth Inhibition Assay		IC50=26.8638 μM	SANGER
NCI-H2122	Growth Inhibition Assay		IC50=26.9998 μM	SANGER
OVCAR-8	Growth Inhibition Assay		IC50=27.0638 μM	SANGER
DJM-1	Growth Inhibition Assay		IC50=27.1454 μM	SANGER
UACC-893	Growth Inhibition Assay		IC50=27.9878 μM	SANGER
C8166	Growth Inhibition Assay		IC50=28.6938 μM	SANGER
NCI-H1693	Growth Inhibition Assay		IC50=28.6975 μM	SANGER
TYK-nu	Growth Inhibition Assay		IC50=30.0345 μM	SANGER
SW1710	Growth Inhibition Assay		IC50=30.126 μM	SANGER
A375	Growth Inhibition Assay		IC50=30.3243 μM	SANGER
HMV-II	Growth Inhibition Assay		IC50=31.3592 μM	SANGER
NCI-H2087	Growth Inhibition Assay		IC50=31.6352 μM	SANGER
CAL-54	Growth Inhibition Assay		IC50=31.7241 μM	SANGER
HCC70	Growth Inhibition Assay		IC50=32.1387 μM	SANGER
ES1	Growth Inhibition Assay		IC50=32.3062 μM	SANGER
NCI-H1355	Growth Inhibition Assay		IC50=33.204 μM	SANGER
CFPAC-1	Growth Inhibition Assay		IC50=33.2332 μM	SANGER
MKN28	Growth Inhibition Assay		IC50=33.3809 μM	SANGER
HDLM-2	Growth Inhibition Assay		IC50=33.6931 μM	SANGER
PANC-10-05	Growth Inhibition Assay		IC50=34.1014 μM	SANGER
SAS	Growth Inhibition Assay		IC50=34.4565 μM	SANGER
HCC1395	Growth Inhibition Assay		IC50=34.7186 μM	SANGER
8305C	Growth Inhibition Assay		IC50=35.8415 μM	SANGER
KM12	Growth Inhibition Assay		IC50=36.7547 μM	SANGER
SW1116	Growth Inhibition Assay		IC50=37.5992 μM	SANGER
SK-MEL-1	Growth Inhibition Assay		IC50=38.3389 μM	SANGER
HCC2218	Growth Inhibition Assay		IC50=38.6519 μM	SANGER
T84	Growth Inhibition Assay		IC50=38.7409 μM	SANGER
ETK-1	Growth Inhibition Assay		IC50=39.022 μM	SANGER
COLO-800	Growth Inhibition Assay		IC50=39.3868 μM	SANGER
CAL-12T	Growth Inhibition Assay		IC50=39.5281 μM	SANGER
ACN	Growth Inhibition Assay		IC50=40.4911 μM	SANGER
SJSA-1	Growth Inhibition Assay		IC50=41.1596 μM	SANGER
PSN1	Growth Inhibition Assay		IC50=41.1749 μM	SANGER
D-566MG	Growth Inhibition Assay		IC50=41.2086 μM	SANGER
EGI-1	Growth Inhibition Assay		IC50=42.428 μM	SANGER
A204	Growth Inhibition Assay		IC50=42.6388 μM	SANGER
Saos-2	Growth Inhibition Assay		IC50=42.8369 μM	SANGER
SNU-C2B	Growth Inhibition Assay		IC50=43.6878 μM	SANGER
HLE	Growth Inhibition Assay		IC50=44.0856 μM	SANGER
SW1463	Growth Inhibition Assay		IC50=44.9971 μM	SANGER
DSH1	Growth Inhibition Assay		IC50=45.0033 μM	SANGER
MCF7	Growth Inhibition Assay		IC50=45.5051 μM	SANGER
K5	Growth Inhibition Assay		IC50=45.9405 μM	SANGER
NCI-H358	Growth Inhibition Assay		IC50=47.215 μM	SANGER
NCI-H2030	Growth Inhibition Assay		IC50=47.2374 μM	SANGER
SW948	Growth Inhibition Assay		IC50=47.464 μM	SANGER
BALL-1	Growth Inhibition Assay		IC50=47.6168 μM	SANGER
TE-9	Growth Inhibition Assay		IC50=47.9581 μM	SANGER
SK-N-FI	Growth Inhibition Assay		IC50=48.0358 μM	SANGER
KALS-1	Growth Inhibition Assay		IC50=48.1289 μM	SANGER
HO-1-N-1	Growth Inhibition Assay		IC50=48.7445 μM	SANGER
NCI-H2452	Growth Inhibition Assay		IC50=49.1152 μM	SANGER
OC-314	Growth Inhibition Assay		IC50=49.6834 μM	SANGER
Cliquez pour voir plus de données expérimentales sur la lignée cellulaire

Informations chimiques, stockage et stabilité

Poids moléculaire	974.61	Formule	C₄₇H₅₅ClF₃N₅O₆S₃	Stockage (À compter de la date de réception)	3 ans-20°Cpoudre
N° CAS	923564-51-6	Télécharger le SDF		Stockage des solutions mères	1 an-80°Cen solvant 1 mois-20°Cen solvant
Synonymes	N/A			Smiles	CC1(CCC(=C(C1)CN2CCN(CC2)C3=CC=C(C=C3)C(=O)NS(=O)(=O)C4=CC(=C(C=C4)NC(CCN5CCOCC5)CSC6=CC=CC=C6)S(=O)(=O)C(F)(F)F)C7=CC=C(C=C7)Cl)C

Solubilité

In vitro
Lot:

DMSO : 100 mg/mL (102.6 mM)
(Le DMSO contaminé par lhumidité peut réduire la solubilité. Utiliser du DMSO frais et anhydre.)

Water : Insoluble

Ethanol : Insoluble

Calculateur de molarité

Masse	Concentration	Volume	Poids moléculaire
=	×	×

Calculateur de dilution Calculateur de poids moléculaire

In vivo Lot:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	2%DMSO 1 40%PEG300 2 5%Tween80 3 53%ddH2O Validé par les laboratoires Selleck. Si vous avez besoin dajustements à cette formulation, contactez notre équipe commerciale pour des tests personnalisés.	0.800mg/ml (0.82mM)	Taking the 1 mL working solution as an example, add 20 μL of 40 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 530 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 Corn oil Validé par les laboratoires Selleck. Si vous avez besoin dajustements à cette formulation, contactez notre équipe commerciale pour des tests personnalisés.	4.000mg/ml (4.10mM)	Taking the 1 mL working solution as an example, add 50 μL of 80 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validé par les laboratoires Selleck. Si vous avez besoin dajustements à cette formulation, contactez notre équipe commerciale pour des tests personnalisés.	1.000mg/ml (1.03mM)	Taking the 1 mL working solution as an example, add 50 μL of 20 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validé par les laboratoires Selleck. Si vous avez besoin dajustements à cette formulation, contactez notre équipe commerciale pour des tests personnalisés.	1.000mg/ml (1.03mM)	Taking the 1 mL working solution as an example, add 50 μL of 20 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validé par les laboratoires Selleck. Si vous avez besoin dajustements à cette formulation, contactez notre équipe commerciale pour des tests personnalisés.	1.550mg/ml (1.59mM)	Taking the 1 mL working solution as an example, add 50 μL of 31 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.

Calculateur de formulation in vivo (Solution claire)

Étape 1 : Saisir les informations ci-dessous (Recommandé : Un animal supplémentaire pour tenir compte des pertes pendant lexpérience)

Dosage : mg/kg Poids moyen des animaux : g Volume de dosage par animal :μL Nombre danimaux :

Étape 2 : Saisir la formulation in vivo (Ceci est seulement le calculateur, pas la formulation. Veuillez nous contacter dabord sil ny a pas de formulation in vivo dans la section Solubilité.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Résultats du calcul :

Concentration de travail : mg/ml;

Méthode de préparation du liquide maître DMSO : mg médicament prédissous dans μL DMSO ( Concentration du liquide maître mg/mL, Veuillez nous contacter dabord si la concentration dépasse la solubilité du DMSO du lot de médicament. )

Méthode de préparation de la formulation in vivo : Prendre μL DMSO liquide maître, puis ajouterμL PEG300, mélanger et clarifier, puis ajouterμL Tween 80, mélanger et clarifier, puis ajouter μL ddH₂O, mélanger et clarifier.

Méthode de préparation de la formulation in vivo : Prendre μL DMSO liquide maître, puis ajouter μL Huile de maïs, mélanger et clarifier.

Note : 1. Veuillez vous assurer que le liquide est clair avant dajouter le solvant suivant.
2. Assurez-vous dajouter le(s) solvant(s) dans lordre. Vous devez vous assurer que la solution obtenue, lors de lajout précédent, est une solution claire avant de procéder à lajout du solvant suivant. Des méthodes physiques telles que le vortex, les ultrasons ou le bain-marie chaud peuvent être utilisées pour faciliter la dissolution.

Mécanisme daction

Targets/IC₅₀/Ki	Bcl-xL (Cell-free assay) <=0.5 nM(Ki) Bcl-2 (Cell-free assay) <=1 nM(Ki) Bcl-w (Cell-free assay) <=1 nM(Ki)
In vitro	Structurellement lié à l'ABT-737, Navitoclax (ABT-263) est un perturbateur des interactions Bcl-2/Bcl-xL avec les protéines pro-apoptotiques. La surexpression des membres de la famille Bcl-2 favorisant la survie est couramment associée au maintien, à la progression et à la chimiorésistance tumorale. Il présente la protection conférée par la surexpression de Bcl-2 ou Bcl-xL avec des valeurs d'EC50 de 60 nM et 20 nM, respectivement. Une large gamme d'activité cellulaire est observée avec ce composé, avec une inhibition de croissance de 50 % (EC50) de 110 nM contre la lignée la plus sensible (H146), tandis que son activité dans la lignée la moins sensible (H82) entraîne une EC50 de 22 μM. Les quatre lignées cellulaires avec des valeurs d'EC50 <400 nM (H146, H889, H1963 et H1417) sont également très sensibles à l'ABT-737, et les deux lignées les plus résistantes (H1048 et H82) sont également résistantes à l'ABT-263.
Essai kinase	Détermination de l'affinité
Essai kinase	Les affinités de liaison (K_i ou IC50) de Navitoclax (ABT-263) contre différentes isoformes de la famille Bcl-2 sont déterminées à l'aide d'essais de polarisation de fluorescence compétitifs. Les paires sonde peptidique/protéine suivantes sont utilisées : f-bad (1 nM) et Bcl-xL (6 nM), f-Bax (1 nM) et Bcl-2 (10 nM), f-Bax (1 nM) et Bcl-w (40 nM), f-Noxa (2 nM) et Mcl-1 (40 nM), et f-Bax (1 nM) et Bcl-2-A1 (15 nM). Ses affinités de liaison pour Bcl-xL sont également déterminées à l'aide d'un essai de transfert d'énergie par résonance de fluorescence résolu dans le temps. Bcl-xL (1 nM, His-tagué) est mélangé avec 200 nM de f-Bak, 1 nM d'anticorps anti-His marqué au Tb, et ce composé à température ambiante pendant 30 min. La fluorescence est mesurée sur un lecteur de plaques Envision à l'aide d'un filtre d'excitation de 340/35 nm et de filtres d'émission de 520/525 (f-Bak) et 495/510 nm (anticorps anti-His marqué au Tb).
In vivo	Navitoclax (ABT-263) démontre une efficacité antitumorale significative lorsqu'il est administré à 100 mg/kg/jour dans le modèle de xénogreffe H345, avec 80 % de TGI et 20 % des tumeurs traitées indiquant au moins une réduction de 50 % du volume tumoral. L'administration orale de ce composé seul provoque des régressions tumorales complètes dans des modèles de xénogreffe de cancer du poumon à petites cellules et de leucémie lymphoblastique aiguë. Dans des modèles de xénogreffe de lymphome à cellules B agressif et de myélome multiple où il présente une activité modeste ou nulle en monothérapie, l'ABT-263 améliore significativement l'efficacité des régimes thérapeutiques cliniquement pertinents.
Références	[1] https://pubmed.ncbi.nlm.nih.gov/18451170/ [2] https://pubmed.ncbi.nlm.nih.gov/18519752/

Applications

Méthodes	Biomarqueurs	Images	PMID
Western blot	STAT3 / pSTAT3 / STAT6 / pSTAT6 / Mcl-1 / Cleaved Mcl-1 / Bcl-xl / Bim / puma / Bik / Bax / PARP / c-Myc caspase3 / cleaved caspase 3		26811457
Growth inhibition assay	Cell viability		25685063

Informations sur lessai clinique

(données du https://clinicaltrials.gov, mis à jour le 2024-05-22)

Numéro NCT	Recrutement	Conditions	Promoteur/Collaborateurs	Date de début	Phases
NCT05358639	Recruiting	High Grade Serous Carcinoma\|Triple Negative Breast Cancer\|Ovarian Cancer	Sunnybrook Health Sciences Centre\|Exactis Innovation\|Centre hospitalier de l''Université de Montréal (CHUM)\|Princess Margaret Hospital Canada	November 9 2022	Phase 1
NCT04480086	Terminated	Myelofibrosis (MF)	AbbVie	March 17 2021	Phase 1
NCT04454658	Active not recruiting	Myelofibrosis (MF)	AbbVie	November 11 2020	Phase 1

Support technique

Instructions de manipulation

Tel: +1-832-582-8158 Ext:3

Si vous avez dautres questions, veuillez laisser un message.

Foire aux questions

Question 1:
Could you tell me if it can go through the hemato-encephalic barrier? This compound has the catalog number S1001.

Réponse :
According to the paper: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3223694/, it cannot cross the brain-blood barrier.

C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):