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Docetaxel inhibiteur de la dépolymérisation des microtubules

Réf. CatalogueS1148

Docetaxel, un analogue du paclitaxel, est un inhibiteur de la dépolymérisation des microtubules en se liant aux microtubules stabilisés.
Docetaxel Microtubule Associated inhibiteur Chemical Structure

Structure chimique

Poids moléculaire: 807.88

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Contrôle Qualité

Lot : Pureté : 99.98%
99.98

Culture cellulaire, traitement et concentration de travail

Lignées cellulaires Type dessai Concentration Temps dincubation Formulation Description de lactivité PMID
HSC-3 Growth Inhibition Assay IC50=0.000132 μM SANGER
5637 Growth Inhibition Assay IC50=0.000143 μM SANGER
HT-144 Growth Inhibition Assay IC50=0.000157 μM SANGER
NCI-H292 Growth Inhibition Assay IC50=0.000159 μM SANGER
HCE-T Growth Inhibition Assay IC50=0.000162 μM SANGER
ESS-1 Growth Inhibition Assay IC50=0.000179 μM SANGER
D-566MG Growth Inhibition Assay IC50=0.000182 μM SANGER
CAL-62 Growth Inhibition Assay IC50=0.000185 μM SANGER
GT3TKB Growth Inhibition Assay IC50=0.000232 μM SANGER
HSC-4 Growth Inhibition Assay IC50=0.000239 μM SANGER
KOSC-2 Growth Inhibition Assay IC50=0.000255 μM SANGER
NB14 Growth Inhibition Assay IC50=0.00026 μM SANGER
ES8 Growth Inhibition Assay IC50=0.00026 μM SANGER
BFTC-905 Growth Inhibition Assay IC50=0.000268 μM SANGER
A498 Growth Inhibition Assay IC50=0.000278 μM SANGER
HO-1-N-1 Growth Inhibition Assay IC50=0.000281 μM SANGER
SF539 Growth Inhibition Assay IC50=0.000302 μM SANGER
HuO-3N1 Growth Inhibition Assay IC50=0.000302 μM SANGER
NCI-H510A Growth Inhibition Assay IC50=0.000336 μM SANGER
CAL-27 Growth Inhibition Assay IC50=0.000339 μM SANGER
TE-8 Growth Inhibition Assay IC50=0.000366 μM SANGER
VA-ES-BJ Growth Inhibition Assay IC50=0.000375 μM SANGER
RH-1 Growth Inhibition Assay IC50=0.000386 μM SANGER
COLO-800 Growth Inhibition Assay IC50=0.000388 μM SANGER
ES7 Growth Inhibition Assay IC50=0.000389 μM SANGER
GAMG Growth Inhibition Assay IC50=0.000416 μM SANGER
Ca9-22 Growth Inhibition Assay IC50=0.000423 μM SANGER
SBC-1 Growth Inhibition Assay IC50=0.00043 μM SANGER
RPMI-7951 Growth Inhibition Assay IC50=0.000448 μM SANGER
SW1710 Growth Inhibition Assay IC50=0.000466 μM SANGER
HGC-27 Growth Inhibition Assay IC50=0.000471 μM SANGER
MC-IXC Growth Inhibition Assay IC50=0.000479 μM SANGER
FTC-133 Growth Inhibition Assay IC50=0.000489 μM SANGER
HT-1080 Growth Inhibition Assay IC50=0.000501 μM SANGER
NMC-G1 Growth Inhibition Assay IC50=0.000517 μM SANGER
GI-1 Growth Inhibition Assay IC50=0.000528 μM SANGER
CGTH-W-1 Growth Inhibition Assay IC50=0.000542 μM SANGER
A2058 Growth Inhibition Assay IC50=0.000544 μM SANGER
ETK-1 Growth Inhibition Assay IC50=0.000558 μM SANGER
NEC8 Growth Inhibition Assay IC50=0.000561 μM SANGER
TE-11 Growth Inhibition Assay IC50=0.000569 μM SANGER
NCI-H720 Growth Inhibition Assay IC50=0.00058 μM SANGER
PSN1 Growth Inhibition Assay IC50=0.000581 μM SANGER
SW780 Growth Inhibition Assay IC50=0.000587 μM SANGER
8-MG-BA Growth Inhibition Assay IC50=0.000589 μM SANGER
EC-GI-10 Growth Inhibition Assay IC50=0.000592 μM SANGER
SJSA-1 Growth Inhibition Assay IC50=0.000615 μM SANGER
639-V Growth Inhibition Assay IC50=0.000647 μM SANGER
PFSK-1 Growth Inhibition Assay IC50=0.000657 μM SANGER
DMS-273 Growth Inhibition Assay IC50=0.000674 μM SANGER
TE-9 Growth Inhibition Assay IC50=0.000676 μM SANGER
SCC-25 Growth Inhibition Assay IC50=0.00068 μM SANGER
PA-1 Growth Inhibition Assay IC50=0.000687 μM SANGER
MHH-ES-1 Growth Inhibition Assay IC50=0.0007 μM SANGER
Daoy Growth Inhibition Assay IC50=0.0007 μM SANGER
G-402 Growth Inhibition Assay IC50=0.000706 μM SANGER
YKG-1 Growth Inhibition Assay IC50=0.000707 μM SANGER
Ca-Ski Growth Inhibition Assay IC50=0.000728 μM SANGER
CHP-212 Growth Inhibition Assay IC50=0.00073 μM SANGER
SCC-4 Growth Inhibition Assay IC50=0.000739 μM SANGER
EW-3 Growth Inhibition Assay IC50=0.000745 μM SANGER
P12-ICHIKAWA Growth Inhibition Assay IC50=0.000745 μM SANGER
HSC-2 Growth Inhibition Assay IC50=0.000755 μM SANGER
HN Growth Inhibition Assay IC50=0.000758 μM SANGER
LXF-289 Growth Inhibition Assay IC50=0.000758 μM SANGER
ES1 Growth Inhibition Assay IC50=0.00077 μM SANGER
NTERA-S-cl-D1 Growth Inhibition Assay IC50=0.000773 μM SANGER
K5 Growth Inhibition Assay IC50=0.000778 μM SANGER
HOS Growth Inhibition Assay IC50=0.000782 μM SANGER
YH-13 Growth Inhibition Assay IC50=0.000791 μM SANGER
SW954 Growth Inhibition Assay IC50=0.000823 μM SANGER
KYSE-510 Growth Inhibition Assay IC50=0.00084 μM SANGER
8505C Growth Inhibition Assay IC50=0.000854 μM SANGER
A549 Growth Inhibition Assay IC50=0.000882 μM SANGER
Detroit562 Growth Inhibition Assay IC50=0.000902 μM SANGER
ES5 Growth Inhibition Assay IC50=0.00091 μM SANGER
KYSE-140 Growth Inhibition Assay IC50=0.000933 μM SANGER
GMS-10 Growth Inhibition Assay IC50=0.000941 μM SANGER
D-263MG Growth Inhibition Assay IC50=0.000947 μM SANGER
BCPAP Growth Inhibition Assay IC50=0.000947 μM SANGER
CHL-1 Growth Inhibition Assay IC50=0.000958 μM SANGER
RKO Growth Inhibition Assay IC50=0.000989 μM SANGER
SW48 Growth Inhibition Assay IC50=0.00101 μM SANGER
BPH-1 Growth Inhibition Assay IC50=0.00102 μM SANGER
EFO-27 Growth Inhibition Assay IC50=0.00102 μM SANGER
CAL-33 Growth Inhibition Assay IC50=0.00104 μM SANGER
NCI-H1792 Growth Inhibition Assay IC50=0.00104 μM SANGER
BB30-HNC Growth Inhibition Assay IC50=0.00105 μM SANGER
VM-CUB-1 Growth Inhibition Assay IC50=0.00105 μM SANGER
TE-5 Growth Inhibition Assay IC50=0.00106 μM SANGER
NB13 Growth Inhibition Assay IC50=0.00107 μM SANGER
NBsusSR Growth Inhibition Assay IC50=0.0011 μM SANGER
LNCaP-Clone-FGC Growth Inhibition Assay IC50=0.0011 μM SANGER
EPLC-272H Growth Inhibition Assay IC50=0.00111 μM SANGER
KNS-62 Growth Inhibition Assay IC50=0.00112 μM SANGER
RERF-LC-MS Growth Inhibition Assay IC50=0.00113 μM SANGER
LOXIMVI Growth Inhibition Assay IC50=0.00116 μM SANGER
KINGS-1 Growth Inhibition Assay IC50=0.00117 μM SANGER
T98G Growth Inhibition Assay IC50=0.00117 μM SANGER
HCC1806 Growth Inhibition Assay IC50=0.00118 μM SANGER
MZ1-PC Growth Inhibition Assay IC50=0.00118 μM SANGER
RT-112 Growth Inhibition Assay IC50=0.00119 μM SANGER
LK-2 Growth Inhibition Assay IC50=0.00121 μM SANGER
A375 Growth Inhibition Assay IC50=0.00121 μM SANGER
SF268 Growth Inhibition Assay IC50=0.00121 μM SANGER
H9 Growth Inhibition Assay IC50=0.00124 μM SANGER
KYSE-410 Growth Inhibition Assay IC50=0.00124 μM SANGER
G-401 Growth Inhibition Assay IC50=0.00127 μM SANGER
SW982 Growth Inhibition Assay IC50=0.00127 μM SANGER
D-423MG Growth Inhibition Assay IC50=0.0013 μM SANGER
CAMA-1 Growth Inhibition Assay IC50=0.00131 μM SANGER
SCC-9 Growth Inhibition Assay IC50=0.00132 μM SANGER
SAS Growth Inhibition Assay IC50=0.00134 μM SANGER
KYSE-180 Growth Inhibition Assay IC50=0.00135 μM SANGER
EW-16 Growth Inhibition Assay IC50=0.00135 μM SANGER
HD-MY-Z Growth Inhibition Assay IC50=0.00141 μM SANGER
KYSE-450 Growth Inhibition Assay IC50=0.00143 μM SANGER
LCLC-97TM1 Growth Inhibition Assay IC50=0.00144 μM SANGER
KS-1 Growth Inhibition Assay IC50=0.00144 μM SANGER
TI-73 Growth Inhibition Assay IC50=0.00144 μM SANGER
A427 Growth Inhibition Assay IC50=0.00148 μM SANGER
LB831-BLC Growth Inhibition Assay IC50=0.00148 μM SANGER
MG-63 Growth Inhibition Assay IC50=0.00151 μM SANGER
PANC-03-27 Growth Inhibition Assay IC50=0.00154 μM SANGER
23132-87 Growth Inhibition Assay IC50=0.00155 μM SANGER
ES4 Growth Inhibition Assay IC50=0.00155 μM SANGER
KP-4 Growth Inhibition Assay IC50=0.00156 μM SANGER
NCI-H1703 Growth Inhibition Assay IC50=0.00157 μM SANGER
MCF7 Growth Inhibition Assay IC50=0.00161 μM SANGER
A172 Growth Inhibition Assay IC50=0.00163 μM SANGER
CAL-39 Growth Inhibition Assay IC50=0.00163 μM SANGER
Saos-2 Growth Inhibition Assay IC50=0.00168 μM SANGER
EW-11 Growth Inhibition Assay IC50=0.00169 μM SANGER
D-336MG Growth Inhibition Assay IC50=0.00169 μM SANGER
SW13 Growth Inhibition Assay IC50=0.00169 μM SANGER
ME-180 Growth Inhibition Assay IC50=0.00169 μM SANGER
SK-MEL-2 Growth Inhibition Assay IC50=0.0017 μM SANGER
697 Growth Inhibition Assay IC50=0.00172 μM SANGER
D-247MG Growth Inhibition Assay IC50=0.00173 μM SANGER
EoL-1-cell Growth Inhibition Assay IC50=0.00173 μM SANGER
MV-4-11 Growth Inhibition Assay IC50=0.00174 μM SANGER
U-2-OS Growth Inhibition Assay IC50=0.00175 μM SANGER
NCI-H526 Growth Inhibition Assay IC50=0.00176 μM SANGER
SK-NEP-1 Growth Inhibition Assay IC50=0.00176 μM SANGER
DB Growth Inhibition Assay IC50=0.00178 μM SANGER
GCT Growth Inhibition Assay IC50=0.0018 μM SANGER
HCT-116 Growth Inhibition Assay IC50=0.00181 μM SANGER
AU565 Growth Inhibition Assay IC50=0.00181 μM SANGER
KALS-1 Growth Inhibition Assay IC50=0.00181 μM SANGER
C2BBe1 Growth Inhibition Assay IC50=0.00182 μM SANGER
Becker Growth Inhibition Assay IC50=0.00183 μM SANGER
647-V Growth Inhibition Assay IC50=0.00184 μM SANGER
NCI-H2122 Growth Inhibition Assay IC50=0.00184 μM SANGER
SBC-5 Growth Inhibition Assay IC50=0.00187 μM SANGER
NB17 Growth Inhibition Assay IC50=0.00189 μM SANGER
MHH-PREB-1 Growth Inhibition Assay IC50=0.00189 μM SANGER
M14 Growth Inhibition Assay IC50=0.00191 μM SANGER
NCI-H1048 Growth Inhibition Assay IC50=0.00192 μM SANGER
CTB-1 Growth Inhibition Assay IC50=0.00192 μM SANGER
SK-PN-DW Growth Inhibition Assay IC50=0.00194 μM SANGER
H4 Growth Inhibition Assay IC50=0.00196 μM SANGER
NCI-SNU-1 Growth Inhibition Assay IC50=0.00197 μM SANGER
M059J Growth Inhibition Assay IC50=0.00198 μM SANGER
OVCAR-5 Growth Inhibition Assay IC50=0.00199 μM SANGER
SK-MEL-28 Growth Inhibition Assay IC50=0.00203 μM SANGER
PC-14 Growth Inhibition Assay IC50=0.00209 μM SANGER
OVCAR-8 Growth Inhibition Assay IC50=0.00212 μM SANGER
BB49-HNC Growth Inhibition Assay IC50=0.00212 μM SANGER
EFM-19 Growth Inhibition Assay IC50=0.00215 μM SANGER
BHY Growth Inhibition Assay IC50=0.00216 μM SANGER
SW756 Growth Inhibition Assay IC50=0.00216 μM SANGER
TE-1 Growth Inhibition Assay IC50=0.00216 μM SANGER
NCI-H2452 Growth Inhibition Assay IC50=0.00216 μM SANGER
NCI-H1581 Growth Inhibition Assay IC50=0.00217 μM SANGER
COR-L23 Growth Inhibition Assay IC50=0.0022 μM SANGER
RXF393 Growth Inhibition Assay IC50=0.00222 μM SANGER
BFTC-909 Growth Inhibition Assay IC50=0.00225 μM SANGER
IST-MEL1 Growth Inhibition Assay IC50=0.00225 μM SANGER
NCI-H650 Growth Inhibition Assay IC50=0.00225 μM SANGER
SK-UT-1 Growth Inhibition Assay IC50=0.00226 μM SANGER
GOTO Growth Inhibition Assay IC50=0.00227 μM SANGER
TYK-nu Growth Inhibition Assay IC50=0.00232 μM SANGER
JVM-3 Growth Inhibition Assay IC50=0.00233 μM SANGER
SK-MES-1 Growth Inhibition Assay IC50=0.00233 μM SANGER
SK-HEP-1 Growth Inhibition Assay IC50=0.00234 μM SANGER
J-RT3-T3-5 Growth Inhibition Assay IC50=0.00235 μM SANGER
A673 Growth Inhibition Assay IC50=0.00235 μM SANGER
NCI-H446 Growth Inhibition Assay IC50=0.00243 μM SANGER
RPMI-2650 Growth Inhibition Assay IC50=0.00246 μM SANGER
HCE-4 Growth Inhibition Assay IC50=0.00247 μM SANGER
KGN Growth Inhibition Assay IC50=0.00247 μM SANGER
U251 Growth Inhibition Assay IC50=0.0025 μM SANGER
BxPC-3 Growth Inhibition Assay IC50=0.00251 μM SANGER
VMRC-RCZ Growth Inhibition Assay IC50=0.00252 μM SANGER
TE-10 Growth Inhibition Assay IC50=0.00254 μM SANGER
OC-314 Growth Inhibition Assay IC50=0.00256 μM SANGER
NCI-H1437 Growth Inhibition Assay IC50=0.0026 μM SANGER
SNU-387 Growth Inhibition Assay IC50=0.00261 μM SANGER
A388 Growth Inhibition Assay IC50=0.00265 μM SANGER
C-33-A Growth Inhibition Assay IC50=0.00266 μM SANGER
CAL-51 Growth Inhibition Assay IC50=0.00271 μM SANGER
Hs-578-T Growth Inhibition Assay IC50=0.00272 μM SANGER
MDA-MB-415 Growth Inhibition Assay IC50=0.00274 μM SANGER
SW1417 Growth Inhibition Assay IC50=0.00276 μM SANGER
HCC70 Growth Inhibition Assay IC50=0.00277 μM SANGER
ES3 Growth Inhibition Assay IC50=0.00277 μM SANGER
KYSE-270 Growth Inhibition Assay IC50=0.00278 μM SANGER
HT-29 Growth Inhibition Assay IC50=0.0028 μM SANGER
MDA-MB-361 Growth Inhibition Assay IC50=0.00281 μM SANGER
RPMI-8866 Growth Inhibition Assay IC50=0.00281 μM SANGER
JEG-3 Growth Inhibition Assay IC50=0.00282 μM SANGER
HT-3 Growth Inhibition Assay IC50=0.00282 μM SANGER
HTC-C3 Growth Inhibition Assay IC50=0.00285 μM SANGER
NCI-H209 Growth Inhibition Assay IC50=0.00286 μM SANGER
SKG-IIIa Growth Inhibition Assay IC50=0.00286 μM SANGER
SW962 Growth Inhibition Assay IC50=0.00293 μM SANGER
LCLC-103H Growth Inhibition Assay IC50=0.00293 μM SANGER
DOK Growth Inhibition Assay IC50=0.00294 μM SANGER
SW1088 Growth Inhibition Assay IC50=0.00295 μM SANGER
GP5d Growth Inhibition Assay IC50=0.00296 μM SANGER
EW-1 Growth Inhibition Assay IC50=0.00298 μM SANGER
CP66-MEL Growth Inhibition Assay IC50=0.003 μM SANGER
DEL Growth Inhibition Assay IC50=0.00301 μM SANGER
DU-4475 Growth Inhibition Assay IC50=0.00302 μM SANGER
HEC-1 Growth Inhibition Assay IC50=0.00303 μM SANGER
U031 Growth Inhibition Assay IC50=0.00307 μM SANGER
BB65-RCC Growth Inhibition Assay IC50=0.00308 μM SANGER
NUGC-3 Growth Inhibition Assay IC50=0.00308 μM SANGER
IST-SL1 Growth Inhibition Assay IC50=0.00312 μM SANGER
LS-411N Growth Inhibition Assay IC50=0.00314 μM SANGER
22RV1 Growth Inhibition Assay IC50=0.00315 μM SANGER
MKN28 Growth Inhibition Assay IC50=0.00317 μM SANGER
ONS-76 Growth Inhibition Assay IC50=0.00322 μM SANGER
SH-4 Growth Inhibition Assay IC50=0.00322 μM SANGER
MIA-PaCa-2 Growth Inhibition Assay IC50=0.00324 μM SANGER
CaR-1 Growth Inhibition Assay IC50=0.00327 μM SANGER
AGS Growth Inhibition Assay IC50=0.00328 μM SANGER
SF126 Growth Inhibition Assay IC50=0.00329 μM SANGER
UACC-62 Growth Inhibition Assay IC50=0.0033 μM SANGER
NCI-H28 Growth Inhibition Assay IC50=0.00334 μM SANGER
A2780 Growth Inhibition Assay IC50=0.00335 μM SANGER
CTV-1 Growth Inhibition Assay IC50=0.00337 μM SANGER
LC-2-ad Growth Inhibition Assay IC50=0.0034 μM SANGER
NCI-H1770 Growth Inhibition Assay IC50=0.00342 μM SANGER
HuO9 Growth Inhibition Assay IC50=0.00346 μM SANGER
U-266 Growth Inhibition Assay IC50=0.00348 μM SANGER
MLMA Growth Inhibition Assay IC50=0.00355 μM SANGER
U-87-MG Growth Inhibition Assay IC50=0.00355 μM SANGER
GI-ME-N Growth Inhibition Assay IC50=0.00358 μM SANGER
HL-60 Growth Inhibition Assay IC50=0.00359 μM SANGER
EGI-1 Growth Inhibition Assay IC50=0.00362 μM SANGER
NCI-H23 Growth Inhibition Assay IC50=0.00364 μM SANGER
NCI-H226 Growth Inhibition Assay IC50=0.00368 μM SANGER
NCI-H520 Growth Inhibition Assay IC50=0.00372 μM SANGER
L-363 Growth Inhibition Assay IC50=0.00376 μM SANGER
CAL-12T Growth Inhibition Assay IC50=0.00376 μM SANGER
BT-20 Growth Inhibition Assay IC50=0.00376 μM SANGER
SNB75 Growth Inhibition Assay IC50=0.00381 μM SANGER
A4-Fuk Growth Inhibition Assay IC50=0.0039 μM SANGER
BE-13 Growth Inhibition Assay IC50=0.00393 μM SANGER
NCI-H1395 Growth Inhibition Assay IC50=0.00396 μM SANGER
SW620 Growth Inhibition Assay IC50=0.00397 μM SANGER
KNS-81-FD Growth Inhibition Assay IC50=0.00399 μM SANGER
RD Growth Inhibition Assay IC50=0.004 μM SANGER
HLE Growth Inhibition Assay IC50=0.00405 μM SANGER
OVCAR-3 Growth Inhibition Assay IC50=0.00407 μM SANGER
KM12 Growth Inhibition Assay IC50=0.00408 μM SANGER
HCC2998 Growth Inhibition Assay IC50=0.00408 μM SANGER
D-502MG Growth Inhibition Assay IC50=0.0041 μM SANGER
KNS-42 Growth Inhibition Assay IC50=0.00412 μM SANGER
LS-123 Growth Inhibition Assay IC50=0.00425 μM SANGER
SiHa Growth Inhibition Assay IC50=0.0043 μM SANGER
T47D Growth Inhibition Assay IC50=0.00431 μM SANGER
EW-24 Growth Inhibition Assay IC50=0.00433 μM SANGER
CAL-120 Growth Inhibition Assay IC50=0.00435 μM SANGER
JAR Growth Inhibition Assay IC50=0.00437 μM SANGER
QIMR-WIL Growth Inhibition Assay IC50=0.00438 μM SANGER
OCUB-M Growth Inhibition Assay IC50=0.00438 μM SANGER
Calu-6 Growth Inhibition Assay IC50=0.00447 μM SANGER
MDA-MB-453 Growth Inhibition Assay IC50=0.00451 μM SANGER
MKN45 Growth Inhibition Assay IC50=0.00453 μM SANGER
ECC10 Growth Inhibition Assay IC50=0.0046 μM SANGER
RVH-421 Growth Inhibition Assay IC50=0.00461 μM SANGER
TGBC11TKB Growth Inhibition Assay IC50=0.00469 μM SANGER
MOLT-4 Growth Inhibition Assay IC50=0.00471 μM SANGER
LN-405 Growth Inhibition Assay IC50=0.00482 μM SANGER
S-117 Growth Inhibition Assay IC50=0.00486 μM SANGER
RPMI-8226 Growth Inhibition Assay IC50=0.00497 μM SANGER
KYSE-150 Growth Inhibition Assay IC50=0.00499 μM SANGER
NCI-H1666 Growth Inhibition Assay IC50=0.00505 μM SANGER
Mewo Growth Inhibition Assay IC50=0.00505 μM SANGER
AN3-CA Growth Inhibition Assay IC50=0.00507 μM SANGER
COLO-680N Growth Inhibition Assay IC50=0.00508 μM SANGER
FADU Growth Inhibition Assay IC50=0.0051 μM SANGER
GB-1 Growth Inhibition Assay IC50=0.00511 μM SANGER
KASUMI-1 Growth Inhibition Assay IC50=0.00511 μM SANGER
NOMO-1 Growth Inhibition Assay IC50=0.00513 μM SANGER
BV-173 Growth Inhibition Assay IC50=0.0053 μM SANGER
RO82-W-1 Growth Inhibition Assay IC50=0.00531 μM SANGER
LB2241-RCC Growth Inhibition Assay IC50=0.00531 μM SANGER
NCI-H2170 Growth Inhibition Assay IC50=0.00535 μM SANGER
SK-N-AS Growth Inhibition Assay IC50=0.00535 μM SANGER
NCI-H1651 Growth Inhibition Assay IC50=0.0054 μM SANGER
NCI-SNU-5 Growth Inhibition Assay IC50=0.00545 μM SANGER
SN12C Growth Inhibition Assay IC50=0.0055 μM SANGER
KY821 Growth Inhibition Assay IC50=0.00551 μM SANGER
SW1573 Growth Inhibition Assay IC50=0.00554 μM SANGER
OE19 Growth Inhibition Assay IC50=0.00559 μM SANGER
MPP-89 Growth Inhibition Assay IC50=0.00567 μM SANGER
HuCCT1 Growth Inhibition Assay IC50=0.00568 μM SANGER
SW1783 Growth Inhibition Assay IC50=0.0057 μM SANGER
8305C Growth Inhibition Assay IC50=0.00576 μM SANGER
OVCAR-4 Growth Inhibition Assay IC50=0.00586 μM SANGER
MMAC-SF Growth Inhibition Assay IC50=0.00586 μM SANGER
COLO-824 Growth Inhibition Assay IC50=0.0059 μM SANGER
HCC38 Growth Inhibition Assay IC50=0.006 μM SANGER
NCI-H1648 Growth Inhibition Assay IC50=0.00601 μM SANGER
NCI-H1573 Growth Inhibition Assay IC50=0.00607 μM SANGER
MFM-223 Growth Inhibition Assay IC50=0.00616 μM SANGER
NCI-H810 Growth Inhibition Assay IC50=0.00622 μM SANGER
EM-2 Growth Inhibition Assay IC50=0.00623 μM SANGER
D-283MED Growth Inhibition Assay IC50=0.00624 μM SANGER
NCI-H1755 Growth Inhibition Assay IC50=0.00624 μM SANGER
KYSE-70 Growth Inhibition Assay IC50=0.00624 μM SANGER
SW626 Growth Inhibition Assay IC50=0.00624 μM SANGER
WM-115 Growth Inhibition Assay IC50=0.00627 μM SANGER
NB69 Growth Inhibition Assay IC50=0.00629 μM SANGER
DOHH-2 Growth Inhibition Assay IC50=0.0063 μM SANGER
MEL-JUSO Growth Inhibition Assay IC50=0.00639 μM SANGER
IGR-1 Growth Inhibition Assay IC50=0.00641 μM SANGER
ACN Growth Inhibition Assay IC50=0.00644 μM SANGER
KARPAS-45 Growth Inhibition Assay IC50=0.00652 μM SANGER
HC-1 Growth Inhibition Assay IC50=0.00656 μM SANGER
MZ2-MEL Growth Inhibition Assay IC50=0.00658 μM SANGER
NCI-H1355 Growth Inhibition Assay IC50=0.00679 μM SANGER
HuP-T4 Growth Inhibition Assay IC50=0.00679 μM SANGER
AsPC-1 Growth Inhibition Assay IC50=0.00683 μM SANGER
SCC-15 Growth Inhibition Assay IC50=0.00689 μM SANGER
CP50-MEL-B Growth Inhibition Assay IC50=0.00693 μM SANGER
DMS-114 Growth Inhibition Assay IC50=0.00696 μM SANGER
KYSE-520 Growth Inhibition Assay IC50=0.007 μM SANGER
NCI-H2228 Growth Inhibition Assay IC50=0.00725 μM SANGER
COLO-829 Growth Inhibition Assay IC50=0.00725 μM SANGER
NCI-H2052 Growth Inhibition Assay IC50=0.00727 μM SANGER
HOP-92 Growth Inhibition Assay IC50=0.0073 μM SANGER
MDA-MB-231 Growth Inhibition Assay IC50=0.0073 μM SANGER
SK-MEL-30 Growth Inhibition Assay IC50=0.00732 μM SANGER
NCI-H2087 Growth Inhibition Assay IC50=0.00748 μM SANGER
SW900 Growth Inhibition Assay IC50=0.00755 μM SANGER
NCI-H358 Growth Inhibition Assay IC50=0.00758 μM SANGER
NCI-H2126 Growth Inhibition Assay IC50=0.00773 μM SANGER
TGBC24TKB Growth Inhibition Assay IC50=0.00781 μM SANGER
786-0 Growth Inhibition Assay IC50=0.00786 μM SANGER
no-10 Growth Inhibition Assay IC50=0.00788 μM SANGER
SCH Growth Inhibition Assay IC50=0.00818 μM SANGER
COLO-741 Growth Inhibition Assay IC50=0.0082 μM SANGER
NCI-H82 Growth Inhibition Assay IC50=0.00822 μM SANGER
MOLT-16 Growth Inhibition Assay IC50=0.00827 μM SANGER
IST-MES1 Growth Inhibition Assay IC50=0.0084 μM SANGER
NCI-H1623 Growth Inhibition Assay IC50=0.00856 μM SANGER
NCI-H1299 Growth Inhibition Assay IC50=0.00857 μM SANGER
SNU-423 Growth Inhibition Assay IC50=0.00857 μM SANGER
ALL-PO Growth Inhibition Assay IC50=0.0086 μM SANGER
DK-MG Growth Inhibition Assay IC50=0.0086 μM SANGER
LB1047-RCC Growth Inhibition Assay IC50=0.0088 μM SANGER
OMC-1 Growth Inhibition Assay IC50=0.00906 μM SANGER
TGBC1TKB Growth Inhibition Assay IC50=0.0091 μM SANGER
DBTRG-05MG Growth Inhibition Assay IC50=0.00917 μM SANGER
HPAF-II Growth Inhibition Assay IC50=0.00926 μM SANGER
A204 Growth Inhibition Assay IC50=0.00934 μM SANGER
TK10 Growth Inhibition Assay IC50=0.00977 μM SANGER
BHT-101 Growth Inhibition Assay IC50=0.0098 μM SANGER
SK-N-DZ Growth Inhibition Assay IC50=0.00983 μM SANGER
ChaGo-K-1 Growth Inhibition Assay IC50=0.00988 μM SANGER
NCI-H661 Growth Inhibition Assay IC50=0.01005 μM SANGER
AM-38 Growth Inhibition Assay IC50=0.01024 μM SANGER
ML-2 Growth Inhibition Assay IC50=0.01029 μM SANGER
TCCSUP Growth Inhibition Assay IC50=0.01036 μM SANGER
SW1990 Growth Inhibition Assay IC50=0.01047 μM SANGER
HCC1395 Growth Inhibition Assay IC50=0.01056 μM SANGER
PANC-10-05 Growth Inhibition Assay IC50=0.01056 μM SANGER
CAKI-1 Growth Inhibition Assay IC50=0.01073 μM SANGER
HuP-T3 Growth Inhibition Assay IC50=0.01077 μM SANGER
HT-1197 Growth Inhibition Assay IC50=0.01084 μM SANGER
MOLT-13 Growth Inhibition Assay IC50=0.01086 μM SANGER
NCI-H1563 Growth Inhibition Assay IC50=0.01087 μM SANGER
NCI-N87 Growth Inhibition Assay IC50=0.01093 μM SANGER
LB373-MEL-D Growth Inhibition Assay IC50=0.01094 μM SANGER
EFO-21 Growth Inhibition Assay IC50=0.011 μM SANGER
LU-134-A Growth Inhibition Assay IC50=0.01102 μM SANGER
DU-145 Growth Inhibition Assay IC50=0.01107 μM SANGER
SF295 Growth Inhibition Assay IC50=0.01126 μM SANGER
ABC-1 Growth Inhibition Assay IC50=0.01146 μM SANGER
TE-6 Growth Inhibition Assay IC50=0.01148 μM SANGER
GAK Growth Inhibition Assay IC50=0.01158 μM SANGER
LU-139 Growth Inhibition Assay IC50=0.01166 μM SANGER
EW-18 Growth Inhibition Assay IC50=0.01169 μM SANGER
MSTO-211H Growth Inhibition Assay IC50=0.01173 μM SANGER
KU812 Growth Inhibition Assay IC50=0.01198 μM SANGER
NCI-H441 Growth Inhibition Assay IC50=0.01198 μM SANGER
LU-99A Growth Inhibition Assay IC50=0.012 μM SANGER
NB10 Growth Inhibition Assay IC50=0.01209 μM SANGER
NCI-H1650 Growth Inhibition Assay IC50=0.01229 μM SANGER
YAPC Growth Inhibition Assay IC50=0.01237 μM SANGER
HT55 Growth Inhibition Assay IC50=0.01242 μM SANGER
NB7 Growth Inhibition Assay IC50=0.01243 μM SANGER
NCI-H2030 Growth Inhibition Assay IC50=0.01254 μM SANGER
EW-22 Growth Inhibition Assay IC50=0.01256 μM SANGER
UMC-11 Growth Inhibition Assay IC50=0.01283 μM SANGER
MKN7 Growth Inhibition Assay IC50=0.01283 μM SANGER
OE33 Growth Inhibition Assay IC50=0.013 μM SANGER
SK-LU-1 Growth Inhibition Assay IC50=0.01324 μM SANGER
LAMA-84 Growth Inhibition Assay IC50=0.01328 μM SANGER
IA-LM Growth Inhibition Assay IC50=0.0133 μM SANGER
HuH-7 Growth Inhibition Assay IC50=0.01354 μM SANGER
J82 Growth Inhibition Assay IC50=0.0139 μM SANGER
CFPAC-1 Growth Inhibition Assay IC50=0.01406 μM SANGER
MN-60 Growth Inhibition Assay IC50=0.01429 μM SANGER
A704 Growth Inhibition Assay IC50=0.01438 μM SANGER
SW684 Growth Inhibition Assay IC50=0.01452 μM SANGER
NOS-1 Growth Inhibition Assay IC50=0.0146 μM SANGER
U-118-MG Growth Inhibition Assay IC50=0.0147 μM SANGER
NCI-H596 Growth Inhibition Assay IC50=0.01477 μM SANGER
RS4-11 Growth Inhibition Assay IC50=0.01516 μM SANGER
KP-N-YS Growth Inhibition Assay IC50=0.01523 μM SANGER
MS-1 Growth Inhibition Assay IC50=0.01545 μM SANGER
A101D Growth Inhibition Assay IC50=0.01549 μM SANGER
DSH1 Growth Inhibition Assay IC50=0.016 μM SANGER
CAS-1 Growth Inhibition Assay IC50=0.01609 μM SANGER
NCI-H2347 Growth Inhibition Assay IC50=0.01636 μM SANGER
T-24 Growth Inhibition Assay IC50=0.01705 μM SANGER
MEG-01 Growth Inhibition Assay IC50=0.01737 μM SANGER
NCI-H2291 Growth Inhibition Assay IC50=0.01838 μM SANGER
SW872 Growth Inhibition Assay IC50=0.01867 μM SANGER
no-11 Growth Inhibition Assay IC50=0.01887 μM SANGER
NB5 Growth Inhibition Assay IC50=0.01891 μM SANGER
MZ7-mel Growth Inhibition Assay IC50=0.01934 μM SANGER
BT-474 Growth Inhibition Assay IC50=0.01943 μM SANGER
OAW-28 Growth Inhibition Assay IC50=0.01956 μM SANGER
ES6 Growth Inhibition Assay IC50=0.02008 μM SANGER
PC-3 Growth Inhibition Assay IC50=0.02036 μM SANGER
COR-L88 Growth Inhibition Assay IC50=0.02054 μM SANGER
D-392MG Growth Inhibition Assay IC50=0.02068 μM SANGER
LB2518-MEL Growth Inhibition Assay IC50=0.02161 μM SANGER
LoVo Growth Inhibition Assay IC50=0.02172 μM SANGER
HCC1954 Growth Inhibition Assay IC50=0.02192 μM SANGER
COLO-792 Growth Inhibition Assay IC50=0.02196 μM SANGER
KLE Growth Inhibition Assay IC50=0.02323 μM SANGER
MDA-MB-157 Growth Inhibition Assay IC50=0.02349 μM SANGER
PANC-08-13 Growth Inhibition Assay IC50=0.02465 μM SANGER
NCI-H727 Growth Inhibition Assay IC50=0.02474 μM SANGER
NCI-H1155 Growth Inhibition Assay IC50=0.02477 μM SANGER
GCIY Growth Inhibition Assay IC50=0.02502 μM SANGER
MKN1 Growth Inhibition Assay IC50=0.02576 μM SANGER
NCI-H1092 Growth Inhibition Assay IC50=0.02654 μM SANGER
RMG-I Growth Inhibition Assay IC50=0.027 μM SANGER
NB12 Growth Inhibition Assay IC50=0.0272 μM SANGER
RCM-1 Growth Inhibition Assay IC50=0.02819 μM SANGER
C3A Growth Inhibition Assay IC50=0.02822 μM SANGER
NCI-H747 Growth Inhibition Assay IC50=0.02837 μM SANGER
LB771-HNC Growth Inhibition Assay IC50=0.02837 μM SANGER
EW-13 Growth Inhibition Assay IC50=0.02904 μM SANGER
CAL-72 Growth Inhibition Assay IC50=0.02918 μM SANGER
HH Growth Inhibition Assay IC50=0.02998 μM SANGER
UACC-257 Growth Inhibition Assay IC50=0.0303 μM SANGER
OAW-42 Growth Inhibition Assay IC50=0.0303 μM SANGER
CAPAN-1 Growth Inhibition Assay IC50=0.03052 μM SANGER
SNU-C2B Growth Inhibition Assay IC50=0.03063 μM SANGER
NKM-1 Growth Inhibition Assay IC50=0.03169 μM SANGER
GR-ST Growth Inhibition Assay IC50=0.03185 μM SANGER
SW1463 Growth Inhibition Assay IC50=0.03337 μM SANGER
MEL-HO Growth Inhibition Assay IC50=0.03421 μM SANGER
NCI-H2342 Growth Inhibition Assay IC50=0.03633 μM SANGER
ACHN Growth Inhibition Assay IC50=0.0371 μM SANGER
RH-18 Growth Inhibition Assay IC50=0.03763 μM SANGER
HCC2218 Growth Inhibition Assay IC50=0.0379 μM SANGER
OS-RC-2 Growth Inhibition Assay IC50=0.03869 μM SANGER
KP-N-YN Growth Inhibition Assay IC50=0.03876 μM SANGER
COLO-668 Growth Inhibition Assay IC50=0.03887 μM SANGER
LU-65 Growth Inhibition Assay IC50=0.03904 μM SANGER
NB6 Growth Inhibition Assay IC50=0.03952 μM SANGER
HT Growth Inhibition Assay IC50=0.04007 μM SANGER
COLO-684 Growth Inhibition Assay IC50=0.04095 μM SANGER
NCI-H1693 Growth Inhibition Assay IC50=0.04305 μM SANGER
LAN-6 Growth Inhibition Assay IC50=0.04335 μM SANGER
MDA-MB-175-VII Growth Inhibition Assay IC50=0.04417 μM SANGER
KMOE-2 Growth Inhibition Assay IC50=0.04469 μM SANGER
DMS-79 Growth Inhibition Assay IC50=0.04579 μM SANGER
MHH-NB-11 Growth Inhibition Assay IC50=0.04614 μM SANGER
NCI-H69 Growth Inhibition Assay IC50=0.04849 μM SANGER
KE-37 Growth Inhibition Assay IC50=0.0501 μM SANGER
Ramos-2G6-4C10 Growth Inhibition Assay IC50=0.05067 μM SANGER
NCI-H1793 Growth Inhibition Assay IC50=0.05093 μM SANGER
HT-1376 Growth Inhibition Assay IC50=0.05186 μM SANGER
EKVX Growth Inhibition Assay IC50=0.05384 μM SANGER
Capan-2 Growth Inhibition Assay IC50=0.05396 μM SANGER
DoTc2-4510 Growth Inhibition Assay IC50=0.05446 μM SANGER
UACC-893 Growth Inhibition Assay IC50=0.05462 μM SANGER
SK-MEL-3 Growth Inhibition Assay IC50=0.05788 μM SANGER
SK-MEL-1 Growth Inhibition Assay IC50=0.058 μM SANGER
SW948 Growth Inhibition Assay IC50=0.05996 μM SANGER
P30-OHK Growth Inhibition Assay IC50=0.06167 μM SANGER
NH-12 Growth Inhibition Assay IC50=0.06244 μM SANGER
KU-19-19 Growth Inhibition Assay IC50=0.06361 μM SANGER
A431 Growth Inhibition Assay IC50=0.06374 μM SANGER
NCI-H2405 Growth Inhibition Assay IC50=0.06383 μM SANGER
KARPAS-299 Growth Inhibition Assay IC50=0.06582 μM SANGER
BALL-1 Growth Inhibition Assay IC50=0.06674 μM SANGER
KURAMOCHI Growth Inhibition Assay IC50=0.07073 μM SANGER
LS-1034 Growth Inhibition Assay IC50=0.07369 μM SANGER
MFE-280 Growth Inhibition Assay IC50=0.07536 μM SANGER
HOP-62 Growth Inhibition Assay IC50=0.07676 μM SANGER
KG-1 Growth Inhibition Assay IC50=0.07787 μM SANGER
CW-2 Growth Inhibition Assay IC50=0.07832 μM SANGER
SW837 Growth Inhibition Assay IC50=0.08342 μM SANGER
MFH-ino Growth Inhibition Assay IC50=0.08501 μM SANGER
HCC1419 Growth Inhibition Assay IC50=0.08987 μM SANGER
HMV-II Growth Inhibition Assay IC50=0.0901 μM SANGER
BEN Growth Inhibition Assay IC50=0.09385 μM SANGER
SK-N-FI Growth Inhibition Assay IC50=0.09556 μM SANGER
JVM-2 Growth Inhibition Assay IC50=0.09716 μM SANGER
CAL-54 Growth Inhibition Assay IC50=0.1004 μM SANGER
T84 Growth Inhibition Assay IC50=0.10952 μM SANGER
SHP-77 Growth Inhibition Assay IC50=0.11641 μM SANGER
G-361 Growth Inhibition Assay IC50=0.12324 μM SANGER
Calu-3 Growth Inhibition Assay IC50=0.13816 μM SANGER
HCC1937 Growth Inhibition Assay IC50=0.14937 μM SANGER
KM-H2 Growth Inhibition Assay IC50=0.1501 μM SANGER
769-P Growth Inhibition Assay IC50=0.15843 μM SANGER
NCI-H1304 Growth Inhibition Assay IC50=0.16061 μM SANGER
D-542MG Growth Inhibition Assay IC50=0.16278 μM SANGER
ATN-1 Growth Inhibition Assay IC50=0.17441 μM SANGER
NCI-H2029 Growth Inhibition Assay IC50=0.20243 μM SANGER
ZR-75-30 Growth Inhibition Assay IC50=0.20643 μM SANGER
SW1116 Growth Inhibition Assay IC50=0.21117 μM SANGER
CCRF-CEM Growth Inhibition Assay IC50=0.27614 μM SANGER
LU-135 Growth Inhibition Assay IC50=0.27739 μM SANGER
MC116 Growth Inhibition Assay IC50=0.28309 μM SANGER
LS-513 Growth Inhibition Assay IC50=0.28773 μM SANGER
NCI-H630 Growth Inhibition Assay IC50=0.29376 μM SANGER
L-428 Growth Inhibition Assay IC50=0.29883 μM SANGER
UM-UC-3 Growth Inhibition Assay IC50=0.31291 μM SANGER
NCI-H1838 Growth Inhibition Assay IC50=0.31784 μM SANGER
HEL Growth Inhibition Assay IC50=0.3224 μM SANGER
OCI-AML2 Growth Inhibition Assay IC50=0.32298 μM SANGER
A3-KAW Growth Inhibition Assay IC50=0.33477 μM SANGER
IGROV-1 Growth Inhibition Assay IC50=0.33755 μM SANGER
Mo-T Growth Inhibition Assay IC50=0.33853 μM SANGER
HDLM-2 Growth Inhibition Assay IC50=0.339 μM SANGER
HCC1569 Growth Inhibition Assay IC50=0.34309 μM SANGER
COLO-678 Growth Inhibition Assay IC50=0.37002 μM SANGER
COR-L105 Growth Inhibition Assay IC50=0.3793 μM SANGER
SK-MEL-24 Growth Inhibition Assay IC50=0.38382 μM SANGER
COLO-320-HSR Growth Inhibition Assay IC50=0.43976 μM SANGER
C8166 Growth Inhibition Assay IC50=0.49023 μM SANGER
COLO-679 Growth Inhibition Assay IC50=0.62172 μM SANGER
TE-12 Growth Inhibition Assay IC50=0.65394 μM SANGER
HAL-01 Growth Inhibition Assay IC50=0.6622 μM SANGER
H-EMC-SS Growth Inhibition Assay IC50=0.70546 μM SANGER
SNU-449 Growth Inhibition Assay IC50=0.72748 μM SANGER
C32 Growth Inhibition Assay IC50=0.74112 μM SANGER
K-562 Growth Inhibition Assay IC50=0.77024 μM SANGER
DJM-1 Growth Inhibition Assay IC50=0.78781 μM SANGER
RCC10RGB Growth Inhibition Assay IC50=0.79183 μM SANGER
CAL-85-1 Growth Inhibition Assay IC50=0.907 μM SANGER
NY Growth Inhibition Assay IC50=0.93352 μM SANGER
NCI-H1993 Growth Inhibition Assay IC50=1.19289 μM SANGER
SK-OV-3 Growth Inhibition Assay IC50=1.22089 μM SANGER
Cliquez pour voir plus de données expérimentales sur la lignée cellulaire

Informations chimiques, stockage et stabilité

Poids moléculaire 807.88 Formule

C43H53NO14

 Stockage (À compter de la date de réception)
N° CAS 114977-28-5 Télécharger le SDF Stockage des solutions mères

Synonymes NSC 628503,RP56976 Smiles CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O

Solubilité

In vitro
Lot:

DMSO : 100 mg/mL (123.78 mM)
(Le DMSO contaminé par lhumidité peut réduire la solubilité. Utiliser du DMSO frais et anhydre.)

Ethanol : 100 mg/mL

Water : Insoluble

Calculateur de molarité

Masse Concentration Volume Poids moléculaire
Calculateur de dilution Calculateur de poids moléculaire

In vivo
Lot:

Calculateur de formulation in vivo (Solution claire)

Étape 1 : Saisir les informations ci-dessous (Recommandé : Un animal supplémentaire pour tenir compte des pertes pendant lexpérience)

mg/kg g μL

Étape 2 : Saisir la formulation in vivo (Ceci est seulement le calculateur, pas la formulation. Veuillez nous contacter dabord sil ny a pas de formulation in vivo dans la section Solubilité.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Résultats du calcul :

Concentration de travail : mg/ml;

Méthode de préparation du liquide maître DMSO : mg médicament prédissous dans μL DMSO ( Concentration du liquide maître mg/mL, Veuillez nous contacter dabord si la concentration dépasse la solubilité du DMSO du lot de médicament. )

Méthode de préparation de la formulation in vivo : Prendre μL DMSO liquide maître, puis ajouterμL PEG300, mélanger et clarifier, puis ajouterμL Tween 80, mélanger et clarifier, puis ajouter μL ddH2O, mélanger et clarifier.

Méthode de préparation de la formulation in vivo : Prendre μL DMSO liquide maître, puis ajouter μL Huile de maïs, mélanger et clarifier.

Note : 1. Veuillez vous assurer que le liquide est clair avant dajouter le solvant suivant.
2. Assurez-vous dajouter le(s) solvant(s) dans lordre. Vous devez vous assurer que la solution obtenue, lors de lajout précédent, est une solution claire avant de procéder à lajout du solvant suivant. Des méthodes physiques telles que le vortex, les ultrasons ou le bain-marie chaud peuvent être utilisées pour faciliter la dissolution.

Mécanisme daction

Targets/IC50/Ki
Microtubules
(Cell-free assay)
In vitro
Docetaxel est un agent cytotoxique, en particulier pour les cellules proliférantes, ce qui est lié à sa capacité à promouvoir la formation de faisceaux de microtubules et à induire un arrêt mitotique soutenu, suivi de l'apoptose des cellules arrêtées en mitose ou d'un blocage mitotique permanent. Ce composé supprime l'instabilité dynamique des microtubules ainsi que le « tread-milling », entraînant l'incapacité des chromosomes à se séparer dans les cellules filles, ce qui déclenche à son tour une sortie prématurée de la mitose plutôt qu'un blocage à cette phase du cycle cellulaire. Il inhibe la survie clonogénique des cellules cancéreuses humaines Hs746T (estomac), AGS (estomac), HeLa (col de l'utérus), CaSki (col de l'utérus), BxPC3 (pancréas), Capan-1 (pancréas) avec une IC50 de 1 nM, 1 nM, 0,3 nM, 0,3 nM, 0,3 nM et 0,3 nM respectivement. Cet agent inhibe la migration des cellules endothéliales qui n'affecte pas la morphologie macroscopique des microtubules ni n'inhibe la prolifération cellulaire, bien qu'il produise des effets plus subtils sur la dynamique des microtubules. Il inhibe la migration des HUVEC avec une IC50 observée de 1 pM. La chimiotaxie des HUVEC stimulée par l'un des deux facteurs angiogéniques, la thymidine phosphorylase ou le VEGF, est inhibée par ce produit chimique avec une IC50 de 10 pM et est abolie à 1 nM. Il induit l'expression de la Prostaglandin H Synthase-2m (PGHS-2) dans les monocytes humains, mais pas dans les macrophages murins RAW 264.7.
In vivo
Docetaxel (33 mg/kg/dose, administré par voie intraveineuse tous les 4 jours pendant 3 injections) entraîne un retard de croissance tumorale de 19,3 jours dans les xénogreffes de côlon M2OL2. Ce composé montre également de grandes activités antitumorales dans les xénogreffes MX-1, SK-MEL-2, LX-1 et OVCAR-3. Il inhibe la réponse angiogénique au facteur de croissance fibroblastique 2 avec une IC50 de 5,4 mg/kg lorsqu'il est injecté deux fois par semaine sur une période de 14 jours, et l'angiogenèse est complètement bloquée chez les souris qui reçoivent 10 mg/kg de ce produit chimique. Il présente une sélectivité pour la migration des cellules endothéliales et/ou la formation de microvaisseaux car l'infiltration des cellules inflammatoires dans le bouchon de Matrigel est beaucoup moins sensible à l'inhibition par ce composé.
Références
  • [4] https://pubmed.ncbi.nlm.nih.gov/7906583/
  • [5] https://pubmed.ncbi.nlm.nih.gov/8664032/
  • [6] https://pubmed.ncbi.nlm.nih.gov/12479700/
  • [7] https://pubmed.ncbi.nlm.nih.gov/9886421/
  • [8] https://pubmed.ncbi.nlm.nih.gov/7499102/

Applications

Méthodes Biomarqueurs Images PMID
Western blot PIM1 cyclin B pSTAT3 / STAT3 p-p53 / p53
S1148-WB1
18426800
Immunofluorescence α-tubulin cleaved PARP / cleaved caspase-3 Acetylated tubulin SQSTM1 / LAMP1
S1148-IF1
27177833
Growth inhibition assay Cell viability
S1148-viability1
22996738

Informations sur lessai clinique

(données du https://clinicaltrials.gov, mis à jour le 2024-05-22)

Numéro NCT Recrutement Conditions Promoteur/Collaborateurs Date de début Phases
NCT06319313 Not yet recruiting
Squamous Cell Non-small Cell Lung Cancer
Shanghai JMT-Bio Inc.
 May 1 2024 Phase 2|Phase 3
NCT06200558 Not yet recruiting
Prostate Cancer
Hospital of Macerata
 January 31 2024 --
NCT05156372 Withdrawn
Prostate Cancer Metastatic|Castrate Resistant Prostate Cancer|Metastatic Prostate Cancer|Metastatic Prostate Adenocarcinoma
The University of Texas Health Science Center at San Antonio
 December 2023 Not Applicable

Support technique

Instructions de manipulation

Tel: +1-832-582-8158 Ext:3

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